Avoid the Eyes, Nose, and Mouth
Tri-Luma Cream is for use on the skin only.
Do not apply it:
- In or around the eyes
- Inside the nose
- Inside the mouth
- On other mucous membranes
- On open or broken skin
If the cream accidentally gets into your eyes, rinse them thoroughly with water.
Sun Sensitivity
Tri-Luma can make your skin more sensitive to sunlight.
During treatment, use a broad-spectrum sunscreen with SPF 30 or higher, wear protective clothing, and limit unnecessary sun exposure.
Avoid tanning beds and sunlamps.
Sun exposure can also make melasma worse and reduce the benefit of treatment.
Skin Irritation
Redness, peeling, burning, dryness, itching, and acne are common during treatment.
Mild irritation may occur as your skin adjusts to the medication.
Stop using Tri-Luma and contact your healthcare provider if you develop severe or persistent irritation, blistering, significant swelling, or another serious skin reaction.
Blue-Black Skin Discoloration
The hydroquinone in Tri-Luma can rarely cause exogenous ochronosis, a condition that causes gradual blue-black darkening of the skin.
Stop using Tri-Luma and contact your healthcare provider if you notice unusual blue-black discoloration.
Skin Thinning
Tri-Luma contains fluocinolone, a topical corticosteroid.
Using corticosteroids for too long can lead to skin thinning, visible small blood vessels, or other changes in the skin.
Use Tri-Luma only for the length of time prescribed.
Hormonal Effects From the Corticosteroid
If enough fluocinolone is absorbed through the skin, it can rarely affect the body’s natural production of corticosteroid hormones.
This risk is more likely with prolonged use or excessive application.
Do not use larger amounts or apply Tri-Luma more often than prescribed.
Allergic Reactions
Do not use Tri-Luma if you are allergic to any of its ingredients.
The cream also contains sodium metabisulfite, which can cause serious allergic reactions in people who are sensitive to sulfites.
Seek immediate medical attention if you develop:
- Hives
- Severe rash
- Swelling of the face, lips, tongue, or throat
- Wheezing or difficulty breathing
Stop using Tri-Luma if a serious allergic reaction occurs.
Pregnancy
Tell your healthcare provider if you are pregnant or planning to become pregnant.
Tri-Luma contains tretinoin, which may harm a developing baby.
Because of this potential risk, Tri-Luma should only be considered during pregnancy when a healthcare provider determines that the potential benefit justifies the risk.
Breastfeeding
Tell your healthcare provider if you are breastfeeding or planning to breastfeed.
It is not known whether enough fluocinolone, hydroquinone, or tretinoin is absorbed through the skin to pass into breast milk.
Avoid applying Tri-Luma to areas where an infant could come into direct contact with the medication.
Worsening Pigmentation
Some people may notice worsening or unusual changes in skin pigmentation instead of improvement.
Contact your healthcare provider if your melasma becomes darker or your skin develops an unexpected color change.
Acne and Other Skin Eruptions
Tri-Luma may cause or worsen acne in some people.
Other skin reactions may include dryness, peeling, redness, burning, itching, or irritation.
Tell your healthcare provider if these effects become severe or persistent.
Other Skin Products and Medications
Tri-Luma may cause more irritation when used with other topical products.
Tell your healthcare provider about all:
- Prescription skin medications
- Over-the-counter creams
- Retinoids
- Acne products
- Exfoliating products
- Cosmetics
- Skin-lightening treatments
Do not add another strong topical treatment without first checking with your healthcare provider.
Use Only as Prescribed
Apply only a thin layer once daily, at least 30 minutes before bedtime.
Do not apply extra cream or use it more often in an attempt to make melasma improve faster.
Tri-Luma is intended for short-term treatment, not continuous long-term use.
Storage
Store Tri-Luma Cream as directed on the product label, away from excessive heat.
Keep the tube tightly closed and out of the reach of children and pets.
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