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Oralair is a prescription medication used to treat moderate to severe seasonal allergies caused by grass pollen.
It contains a standardized extract of five different grass pollens and belongs to a class of medications called allergen immunotherapy.
Unlike antihistamines, which temporarily relieve allergy symptoms, Oralair works by gradually changing how the immune system responds to grass pollen. This process is called desensitization.
Oralair is available as a sublingual tablet, meaning it is placed under the tongue and allowed to dissolve.
It is prescribed to patients with confirmed grass pollen allergies who experience symptoms such as nasal congestion, sneezing, a runny nose, nasal itching, and itchy or watery eyes.
In Canada, Oralair is approved for patients aged 5 to 50 years who have experienced moderate to severe seasonal grass pollen allergy symptoms for at least two pollen seasons and have not responded adequately to, or tolerated, conventional allergy treatments.
Oralair helps reduce the severity of grass pollen allergy symptoms by gradually decreasing the immune system’s sensitivity to specific grass allergens. It is a preventive treatment rather than a medication for immediate allergy relief.Â
Oralair is used to treat seasonal allergic rhinitis caused by grass pollen.
Seasonal allergic rhinitis, commonly called hay fever, occurs when the immune system reacts excessively to airborne allergens that are present during certain times of the year.
Grass pollen is one of the most common triggers of seasonal allergies, particularly during spring and summer.
When grass pollen enters the nose, the immune system may mistakenly identify it as harmful and release substances such as histamine.
These substances cause inflammation and irritation in the nasal passages, resulting in symptoms such as sneezing, nasal congestion, itching, and a runny nose.
Some patients may also experience postnasal drip, throat irritation, and difficulty sleeping because of persistent nasal symptoms.
Oralair works by gradually helping the immune system become less reactive to the grass pollens contained in the medication.
With regular treatment, patients may experience fewer or less severe allergy symptoms during grass pollen season.
This may also reduce the need for certain medications used to control seasonal allergies, although some patients may still require additional symptom relief.
Unlike antihistamines or nasal sprays that provide relatively quick relief, Oralair is usually started approximately four months before the expected grass pollen season and continued throughout the season.
Oralair helps reduce nasal congestion, sneezing, itching, and a runny nose caused by grass pollen allergies. Consistent treatment before and during pollen season is important for achieving the intended benefits.
Oralair may also help relieve eye symptoms associated with seasonal grass pollen allergies.
Allergic conjunctivitis occurs when the immune system reacts to allergens that come into contact with the eyes.
The conjunctiva is a thin membrane that covers the white part of the eye and lines the inside of the eyelids.
When this membrane becomes irritated by allergens, patients may experience itching, redness, watering, swelling, and discomfort.
Grass pollen can trigger these symptoms, particularly during periods when pollen levels are high.
Some patients experience both allergic rhinitis and allergic conjunctivitis at the same time. This combination is called allergic rhinoconjunctivitis.
Oralair helps reduce the immune system’s sensitivity to grass pollen, which may improve both nasal and eye-related allergy symptoms.
However, Oralair is not an eye drop and should never be placed directly into the eyes.
It is taken under the tongue and works through the immune system rather than acting directly on the eye’s surface.
Patients with severe eye irritation may still require additional treatments, such as allergy eye drops, depending on their healthcare provider’s recommendations.
Oralair may help relieve itchy, red, and watery eyes associated with grass pollen allergies, particularly when these symptoms occur alongside seasonal allergic rhinitis.Â
Oralair contains extracts from five different grass species commonly associated with seasonal allergic reactions.
These include sweet vernal grass, orchard grass, perennial ryegrass, timothy grass, and Kentucky bluegrass.
Each species produces pollen that can trigger allergic reactions in susceptible individuals.
Some patients may react to one type of grass pollen, while others may be sensitive to several.
Oralair is formulated with a mixture of these pollens to help the immune system develop greater tolerance to the allergens.
Before prescribing Oralair, a healthcare provider or allergy specialist will confirm the patient’s sensitivity to grass pollen.
This may involve reviewing the patient’s allergy symptoms and performing skin prick testing or blood tests that measure allergen-specific immunoglobulin E (IgE) antibodies.
IgE is an antibody involved in allergic reactions.
These tests help determine whether grass pollen is responsible for the patient’s symptoms and whether Oralair is an appropriate treatment.
Oralair is not intended to treat allergies caused by unrelated substances such as dust mites, pet dander, mold, or food allergens.
Oralair is specifically formulated for allergies involving five grass pollen species. A confirmed grass pollen allergy is necessary before treatment begins.Â
Oralair works through a treatment process called sublingual allergen immunotherapy (SLIT).
This type of immunotherapy involves exposing the immune system to carefully controlled amounts of a specific allergen.
In patients with grass pollen allergies, the immune system mistakenly identifies grass pollen as a harmful substance.
This triggers the release of histamine and other inflammatory chemicals, which cause symptoms such as sneezing, nasal congestion, itching, and watery eyes.
Oralair contains standardized amounts of grass pollen allergens that are administered under the tongue.
Over time, repeated exposure may help the immune system become less sensitive to those allergens.
Gradually Reduces Allergen Sensitivity
Oralair introduces controlled amounts of grass pollen allergens to the immune system.
With continued treatment, the body may develop greater tolerance to these substances.
Changes the Immune Response
Allergen immunotherapy can influence immune cells and antibodies involved in allergic reactions.
These changes may reduce the intensity of the immune response when the patient encounters grass pollen naturally.
Reduces Allergy-Related Inflammation
As the immune system becomes less reactive, the release and effects of inflammatory substances may decrease.
This can help reduce nasal and eye-related allergy symptoms during pollen season.
Provides Seasonal Symptom Control
Oralair is generally taken daily, beginning approximately four months before the expected grass pollen season and continuing until the season ends.
Its benefits develop gradually rather than immediately.
Oralair works by helping the immune system build tolerance to specific grass pollen allergens, reducing the severity of seasonal allergic reactions over time.
Oralair does not provide immediate relief from allergy symptoms.
Unlike antihistamines, nasal decongestants, or certain allergy eye drops, it works by gradually modifying the immune system’s response to grass pollen.
This process requires consistent treatment over an extended period.
Oralair is generally started approximately four months before the expected beginning of grass pollen season.
Treatment continues throughout the pollen season to help reduce symptoms when grass pollen exposure increases.
Some patients may notice improvement during their first treatment season, while others may require additional seasonal treatment to achieve a satisfactory response.
The degree of improvement varies depending on the severity of the allergy, individual immune response, and consistency of treatment.
Your healthcare provider will periodically evaluate whether Oralair is providing meaningful symptom relief.
Oralair requires several months of consistent treatment before the grass pollen season to achieve its intended benefits. It should not be used for immediate relief of sudden allergy symptoms.Â
Oralair is available as sublingual tablets containing standardized grass pollen extract, with strengths of 100 IR and 300 IR.
IR stands for Index of Reactivity, a measure used to describe the allergenic activity of the extract.
The appropriate dosage depends on the patient’s age and treatment plan.
The first dose must be administered under medical supervision because Oralair can cause serious allergic reactions, including anaphylaxis.
Patients are generally observed for at least 30 minutes after their first dose.
Once the initial dose has been tolerated, subsequent doses may usually be taken at home as prescribed. Children should take Oralair under adult supervision.
Common side effects may include itching or irritation in the mouth, throat discomfort, and swelling or tingling around the tongue.
In rare cases, Oralair can cause severe allergic reactions involving difficulty breathing, throat swelling, or a dangerous drop in blood pressure.
Patients may need access to an epinephrine auto-injector, depending on their prescribing guidance and individual risk.
Oralair should not be used in patients with severe, unstable, or uncontrolled asthma. It is also contraindicated in certain patients with eosinophilic esophagitis or a history of severe allergic reactions to sublingual allergen immunotherapy.
Seek emergency medical attention if you develop difficulty breathing, throat tightness, severe dizziness, or swelling of the tongue or throat after taking Oralair.
Oralair is a prescription medication used to treat seasonal allergic rhinitis, with or without allergic conjunctivitis, caused by grass pollen.
It contains standardized extracts from five different grass pollens and belongs to a class of treatments called sublingual allergen immunotherapy (SLIT).
Unlike antihistamines, which provide temporary symptom relief, Oralair works by gradually reducing the immune system’s sensitivity to grass pollen. This may help decrease sneezing, nasal congestion, a runny nose, and itchy or watery eyes during allergy season.
Oralair is available as a sublingual tablet, meaning it is placed under the tongue and allowed to dissolve rather than swallowed immediately.
Treatment is generally taken once daily and should begin approximately four months before the expected start of grass pollen season. It is then continued throughout the season.
Because Oralair contains allergens that can trigger serious allergic reactions, the first dose must be administered under medical supervision.
Take Oralair exactly as prescribed. Do not chew, crush, or immediately swallow the tablet, and never increase your dosage without medical guidance.
Oralair should be taken by placing the prescribed tablet directly under the tongue.
Proper administration is important because the medication is designed to interact with immune tissues in the mouth.
Follow these steps when taking Oralair:
It is generally recommended to take Oralair in the morning with an empty mouth.
Try to take your medication at approximately the same time each day to maintain a consistent treatment schedule.
Allow Oralair to dissolve completely under your tongue for at least one minute before swallowing. Avoid food and drinks for five minutes afterward.Â
The first dose of Oralair must be administered in a healthcare setting under the supervision of a healthcare professional experienced in treating allergic reactions.
This precaution is necessary because Oralair contains grass pollen allergens that may trigger an allergic reaction, including anaphylaxis.
Anaphylaxis is a severe, potentially life-threatening allergic reaction that can affect breathing, blood pressure, and other vital functions.
After receiving the first dose, patients must remain under medical observation for at least 30 minutes.
During this period, healthcare professionals monitor for signs of an allergic reaction, including throat swelling, difficulty breathing, dizziness, and changes in blood pressure.
If the first dose is tolerated, subsequent doses can generally be taken at home according to the prescribed treatment plan.
Patients should understand how to recognize a serious allergic reaction and how to respond if one develops.
Depending on the applicable prescribing guidance, patients may be prescribed an epinephrine auto-injector and instructed in its proper use.
Never take your first Oralair dose at home. The initial dose requires medical supervision and at least 30 minutes of observation.Â
The recommended dosage of Oralair depends on the patient’s age, country-specific prescribing instructions, and treatment stage.
Under Canadian prescribing guidance, adults and children aged five years and older generally begin with a three-day dose escalation schedule.
This allows treatment to begin at a lower dose before reaching the regular maintenance dose.
| Treatment day | Recommended dose |
| Day 1 | One 100 IR tablet |
| Day 2 | Two 100 IR tablets taken together |
| Day 3 onward | One 300 IR tablet once daily |
IR stands for Index of Reactivity, a standardized measure of allergen activity.
On the second day, both 100 IR tablets should be placed under the tongue simultaneously and allowed to dissolve completely before swallowing.
Starting on the third day, the usual maintenance dose is one 300 IR tablet daily.
The dose escalation schedule differs under U.S. prescribing information, so patients should follow the instructions provided with their specific prescription.
Follow the dosage schedule prescribed by your allergy specialist. Do not skip the initial dose escalation steps or independently change your maintenance dose.Â
Oralair may be prescribed to children with confirmed grass pollen allergies who meet the applicable age and treatment requirements.
In Canada, Oralair is approved for certain patients aged five to 50 years.
Children should take Oralair only under the supervision of a responsible adult.
An adult should help the child remove the tablet from its packaging, place it correctly under the tongue, and follow the administration instructions.
Children should be reminded not to chew or immediately swallow the tablet.
The first dose must be given in a medical setting, followed by at least 30 minutes of observation.
For subsequent doses at home, an adult should supervise administration and monitor for symptoms of an allergic reaction. A mandatory 30-minute observation period after every home dose is not specified in the same way as the first-dose observation, but caregivers should follow their allergy specialist’s instructions.
If a child develops throat tightness, difficulty breathing, severe swelling, or another serious allergic reaction, stop treatment and seek emergency medical attention.
Children should take Oralair under adult supervision. Caregivers must understand how to recognize allergic reactions and follow the prescribed emergency treatment plan.
Oralair is generally started approximately four months before the expected beginning of grass pollen season.
Beginning treatment before pollen exposure increases allows time for the immune system to gradually become less sensitive to grass allergens.
The exact starting date depends on the expected pollen season in your region and your healthcare provider’s recommendations.
Treatment continues daily throughout grass pollen season.
Oralair is not intended to provide immediate relief from sudden allergic reactions.
Patients may still need other allergy medications, such as antihistamines or nasal sprays, to control symptoms while immunotherapy takes effect.
Your allergy specialist will evaluate your response and determine whether additional seasonal treatment is appropriate.
Start Oralair approximately four months before grass pollen season and continue taking it daily throughout the season as prescribed.
If you forget to take a dose of Oralair, skip the missed dose and resume treatment at your next regularly scheduled time.
Do not take two doses together to compensate for a missed tablet.
Taking more Oralair than prescribed may increase the risk of local or systemic allergic reactions.
If you miss several doses, the appropriate steps depend on how long treatment has been interrupted.
Under Canadian prescribing guidance, patients who interrupt maintenance treatment for less than one week may generally resume their previous schedule.
However, if you miss more than seven consecutive days, contact your healthcare provider before restarting Oralair.
After a prolonged interruption, treatment may need to be restarted under medical supervision because the risk of allergic reactions may be greater.
Do not independently repeat the initial dose escalation schedule or restart at a lower dose unless instructed.
Never double your Oralair dose. If treatment has been interrupted for more than seven days, consult your healthcare provider before restarting.Â
Oralair is generally taken daily throughout the grass pollen season after treatment begins approximately four months beforehand.
The duration of treatment may vary depending on the patient’s allergy history, treatment response, and healthcare provider’s recommendations.
Some patients may benefit from treatment over multiple consecutive pollen seasons.
Your allergy specialist will assess whether Oralair has meaningfully reduced your allergy symptoms and whether continued treatment is appropriate.
Do not stop taking Oralair simply because symptoms improve.
However, if you experience a serious allergic reaction or another significant adverse effect, stop treatment and seek appropriate medical care.
Continue taking Oralair for the prescribed seasonal treatment period. Your allergy specialist will determine whether further courses are necessary.
Certain medical conditions or symptoms may require Oralair treatment to be temporarily interrupted.
For example, Oralair should not be taken when there is significant inflammation, injury, or an open wound inside the mouth.
This may include mouth ulcers, oral infections, or recent dental procedures that leave damaged oral tissue.
These conditions may increase allergen absorption and potentially increase the risk of adverse reactions.
Your healthcare provider may recommend waiting until the mouth has healed before restarting treatment.
Patients who experience a significant worsening of asthma symptoms should also stop treatment and contact their healthcare provider promptly.
Persistent difficulty swallowing, chest discomfort associated with swallowing, or significant throat symptoms may require evaluation for eosinophilic esophagitis, an inflammatory condition affecting the esophagus.
Contact your healthcare provider before continuing Oralair if you develop mouth wounds, significant oral inflammation, worsening asthma, or persistent swallowing difficulties.
Oralair may cause local allergic reactions because it contains grass pollen allergens.
Mild reactions may include itching in the mouth, tingling beneath the tongue, throat irritation, or mild swelling inside the mouth.
These symptoms are more common during the early stages of treatment and may improve as treatment continues.
However, some reactions may become severe.
Warning signs of a serious allergic reaction include difficulty breathing, swelling of the tongue or throat, throat tightness, trouble swallowing or speaking, severe dizziness, fainting, or widespread hives accompanied by other symptoms.
If these symptoms occur, stop taking Oralair immediately.
Use an epinephrine auto-injector if one has been prescribed and you have been instructed to use it, then seek emergency medical attention. Do not delay emergency care.
Do not restart Oralair after a severe reaction unless your allergy specialist specifically determines that it is appropriate.
Seek emergency medical attention for difficulty breathing, throat swelling, fainting, or other symptoms of anaphylaxis after taking Oralair.Â
Oralair should only be prescribed by a healthcare professional experienced in diagnosing and managing allergic conditions.
It should not be used in patients with severe, unstable, or uncontrolled asthma, or in patients with certain histories of serious allergic reactions to sublingual immunotherapy.
Patients with eosinophilic esophagitis should not take Oralair.
Tell your healthcare provider about all medications you take, particularly medications that may interfere with the treatment of a severe allergic reaction.
Patients should also inform their allergy specialist about recent dental procedures, oral infections, worsening asthma, or other significant medical changes.
Take Oralair exactly as prescribed, supervise administration in children, avoid eating or drinking for five minutes after the tablet dissolves, and follow your healthcare provider’s instructions for missed doses and allergic reactions.
Oralair (Grass Pollen Extract) is available in the following forms and strengths:
Oralair is a prescription medication used to treat seasonal allergic rhinitis, with or without allergic conjunctivitis, caused by grass pollen.
It contains standardized extracts from five grass pollen species and belongs to a class of treatments called sublingual allergen immunotherapy (SLIT).
Unlike antihistamines, which temporarily relieve allergy symptoms, Oralair works by gradually reducing the immune system’s sensitivity to grass pollen. This process may help decrease sneezing, nasal congestion, a runny nose, and itchy or watery eyes during grass pollen season.
Although Oralair can help control seasonal allergies, it contains the allergens responsible for triggering allergic reactions. Consequently, it may occasionally cause serious side effects, including life-threatening anaphylaxis.
Oralair should only be started under the supervision of an allergy specialist. Patients must understand how to recognize and respond to serious allergic reactions before beginning treatment.Â
One of the most important precautions associated with Oralair is the risk of severe allergic reactions.
Oralair contains grass pollen allergens that are administered under the tongue to help the immune system gradually develop tolerance.
However, exposure to these allergens may sometimes trigger an excessive immune response.
A severe allergic reaction, called anaphylaxis, can affect the airways, heart, blood circulation, and other organs.
Symptoms may include difficulty breathing, chest or throat tightness, swelling of the lips or tongue, difficulty swallowing, severe dizziness, fainting, or a rapid or weak heartbeat.
Some patients may also experience widespread hives, severe itching, abdominal cramps, vomiting, or diarrhea.
Because these reactions can become life-threatening, the first dose of Oralair must be administered in a healthcare setting.
Patients must remain under medical observation for at least 30 minutes after the first dose.
For treatment at home, patients should follow their allergy specialist’s emergency plan. Under U.S. prescribing guidance, patients are prescribed an epinephrine auto-injector and instructed on its use.
Stop taking Oralair and seek emergency medical attention if you develop difficulty breathing, throat swelling, severe dizziness, or other signs of anaphylaxis. Use prescribed epinephrine immediately when indicated, and do not delay emergency care.Â
Oralair should not be used in patients with severe, unstable, or uncontrolled asthma.
Asthma is a chronic respiratory condition that causes inflammation and narrowing of the airways.
Symptoms may include wheezing, coughing, chest tightness, and shortness of breath.
Patients whose asthma is poorly controlled may have an increased risk of serious breathing complications if they experience an allergic reaction to Oralair.
For example, an allergic reaction that affects the airways may be especially dangerous in someone who already has significant breathing difficulties.
Before prescribing Oralair, your healthcare provider will assess your respiratory history and determine whether your asthma is adequately controlled.
Patients with mild or well-controlled asthma may still require careful evaluation and monitoring.
If your asthma symptoms become worse during treatment, stop taking Oralair and contact your healthcare provider promptly.
Do not take Oralair if you have severe, unstable, or uncontrolled asthma. Seek emergency medical attention if you experience significant difficulty breathing or rapidly worsening respiratory symptoms.
Oralair should not be used by patients with certain histories of severe allergic reactions.
This includes patients who have previously experienced a severe systemic allergic reaction or a serious local reaction involving the throat or upper airways during sublingual allergen immunotherapy.
Patients with known hypersensitivity to any inactive ingredient in Oralair should also avoid the medication.
It is important to distinguish an ordinary grass pollen allergy from a previous severe reaction to immunotherapy.
Oralair is specifically intended for patients with confirmed grass pollen allergies. Therefore, having a grass pollen allergy is not, by itself, a reason to avoid treatment.
However, patients who have experienced anaphylaxis or another serious allergic reaction require careful assessment before starting immunotherapy.
Tell your allergy specialist about any previous reactions involving difficulty breathing, throat swelling, fainting, or emergency treatment.
Inform your healthcare provider about any history of anaphylaxis or severe reactions to allergy immunotherapy. Do not use Oralair if you have a contraindication identified in the prescribing information.Â
Oralair should be taken consistently according to your prescribed treatment schedule.
Treatment generally begins approximately four months before the expected grass pollen season and continues throughout the season.
Regular dosing helps maintain the immune system’s gradual adaptation to grass pollen allergens.
Stopping Oralair unexpectedly may reduce treatment effectiveness, particularly if multiple doses are missed.
However, abruptly stopping Oralair is not known to cause an allergic reaction simply because the medication was discontinued.
The more important concern is that restarting treatment after a prolonged interruption may require additional medical supervision.
Under Canadian prescribing guidance, patients who interrupt treatment for more than seven days should contact their healthcare provider before restarting.
Treatment may need to be resumed under medical observation, depending on the interruption and individual circumstances.
Oralair should also be temporarily stopped when certain safety problems arise, including serious allergic reactions, worsening asthma, or significant mouth injuries.
Do not restart Oralair after an interruption of more than seven days without medical advice. If you experience a serious allergic reaction, stop treatment immediately and follow your emergency care plan.Â
Tell your healthcare provider if you are pregnant, planning to become pregnant, or think you may be pregnant before using Oralair.
There is limited information about the safety of Oralair during human pregnancy.
Although allergen immunotherapy may help reduce allergy symptoms, it also carries a risk of severe allergic reactions.
Anaphylaxis during pregnancy can affect blood pressure and oxygen delivery, potentially placing both the mother and developing baby at risk.
For this reason, starting allergen immunotherapy during pregnancy is generally avoided unless a specialist determines that the potential benefits justify the risks.
If you become pregnant while already receiving Oralair, your allergy specialist will assess whether treatment should continue.
The decision depends on your tolerance of treatment, allergy severity, and overall medical condition.
Do not independently increase your dosage or restart treatment after an interruption.
Consult your allergy specialist if you are pregnant or planning pregnancy. Oralair should only be used during pregnancy when the potential benefits outweigh the possible risks.Â
Before starting Oralair, tell your healthcare provider about all prescription medications, over-the-counter products, vitamins, and herbal supplements you take.
Although Oralair is not generally associated with the same metabolic drug interactions as many conventional medications, certain drugs may affect the treatment of a serious allergic reaction.
For example, beta-blockers used for certain heart conditions or high blood pressure may make anaphylaxis more difficult to manage and may reduce the response to epinephrine.
Patients taking these medications require careful assessment before starting allergen immunotherapy.
Certain antidepressants, including tricyclic antidepressants, and monoamine oxidase inhibitors may also complicate the use of epinephrine because they can intensify some of its cardiovascular effects.
If you receive other forms of allergy immunotherapy, inform your specialist because combining treatments may increase the overall risk of allergic reactions.
Do not stop prescribed heart, blood pressure, or psychiatric medications without medical advice.
Provide your allergy specialist with a complete medication list before starting Oralair, particularly if you take beta-blockers or medications that may affect emergency treatment with epinephrine.Â
Oralair should be taken under the tongue without food or beverages in the mouth.
The tablet is designed to dissolve beneath the tongue, allowing grass pollen allergens to interact with immune tissues in the oral cavity.
Eating or drinking while the tablet dissolves may interfere with proper administration.
Place Oralair under your tongue and allow it to dissolve completely before swallowing, following the instructions for your prescribed product.
Do not eat or drink while the tablet is dissolving or for at least five minutes afterward.
Although the original precautions suggest avoiding food and drinks for five minutes before treatment, the manufacturer’s standard instructions specifically emphasize taking the tablet with an empty mouth and avoiding food and beverages for five minutes afterward.
Taking Oralair consistently and using the correct technique helps ensure proper administration.
Take Oralair with an empty mouth and avoid eating or drinking for at least five minutes after the tablet has dissolved.Â
Patients taking Oralair should pay attention to oral hygiene and avoid activities that may irritate the mouth immediately before treatment.
Brushing teeth vigorously, using irritating mouthwash, or chewing gum may sometimes cause minor injuries or irritation in sensitive oral tissues.
Because Oralair is absorbed through tissues beneath the tongue, inflammation or damaged tissue may increase the risk of local reactions.
However, a universal restriction against brushing teeth, using mouthwash, or chewing gum for 30 minutes before and after every dose is not specified in the standard Oralair prescribing instructions.
The more important precaution is to avoid taking Oralair when you have mouth sores, bleeding, significant inflammation, or wounds that have not healed.
If brushing your teeth causes bleeding or irritation, contact your healthcare provider for advice about when to take the medication.
Avoid using products that cause significant burning or irritation immediately before placing the tablet under your tongue.
Maintain good oral hygiene, but avoid taking Oralair when your mouth is injured, bleeding, or significantly inflamed. Follow any additional timing instructions provided by your allergy specialist.
Oralair should be temporarily discontinued when patients develop significant injuries or inflammation inside the mouth.
This includes mouth ulcers, oral infections, cuts, or wounds caused by dental procedures.
For example, tooth extraction and certain oral surgeries may leave areas of damaged tissue that require time to heal.
Because Oralair is administered beneath the tongue, damaged oral tissues may allow increased exposure to grass pollen allergens.
This may increase the risk of allergic reactions.
If you have a dental procedure scheduled, tell your dentist and allergy specialist that you are receiving Oralair treatment.
Your healthcare provider may recommend stopping Oralair until the mouth has completely healed.
If treatment has been interrupted for more than seven days, restarting may require medical supervision.
Stop Oralair temporarily and contact your healthcare provider if you develop mouth ulcers, oral wounds, significant oral infections, or undergo dental surgery. Do not restart until your healthcare provider confirms that it is safe.Â
Patients receiving Oralair should continue taking reasonable precautions to reduce exposure to grass pollen.
Although Oralair helps the immune system become less sensitive to grass allergens, it does not completely prevent allergic reactions.
Symptoms may still occur when pollen levels are particularly high.
For example, patients may experience sneezing, nasal congestion, itchy eyes, or other allergy symptoms after spending prolonged periods outdoors during peak grass pollen season.
Natural pollen exposure is not generally a reason to stop Oralair automatically, and there is no universal requirement to avoid all outdoor activities during treatment.
However, minimizing unnecessary exposure may help reduce symptoms and improve comfort.
Consider monitoring local pollen forecasts, keeping windows closed during periods of high pollen, and changing clothes after prolonged outdoor exposure.
Patients should also follow their healthcare provider’s recommendations concerning additional allergy medications.
If you experience unusually severe symptoms or a systemic allergic reaction, seek medical advice promptly.
Oralair does not eliminate the need for allergen avoidance. Reduce unnecessary exposure to high grass pollen levels and contact your healthcare provider if allergy symptoms become severe or difficult to control.
Patients taking Oralair should monitor for new or worsening symptoms throughout treatment.
Mild local reactions, such as itching beneath the tongue, tingling in the mouth, or mild throat irritation, are relatively common when treatment begins.
These reactions may improve as the body becomes accustomed to the medication.
However, persistent or progressively worsening symptoms may require medical assessment.
For example, significant swelling of the tongue, throat tightness, difficulty swallowing, or worsening breathing problems may indicate a serious allergic reaction.
Other symptoms, such as severe stomach pain, vomiting, dizziness, or fainting, may also require urgent attention.
Do not assume that every reaction is harmless simply because Oralair commonly causes mild mouth irritation.
Your healthcare provider may recommend temporarily interrupting treatment or discontinuing it if adverse reactions become significant.
Report persistent or worsening symptoms to your allergy specialist. Seek emergency medical attention for difficulty breathing, significant throat swelling, fainting, or other signs of a severe allergic reaction.Â
Oralair should not be used in patients with a history of eosinophilic esophagitis.
Eosinophilic esophagitis is an inflammatory condition affecting the esophagus, the tube that carries food from the mouth to the stomach.
The condition occurs when eosinophils, a type of white blood cell, accumulate in the esophageal lining and contribute to inflammation.
Symptoms may include difficulty swallowing, pain when swallowing, persistent heartburn, chest discomfort, or food becoming stuck in the throat or chest.
Eosinophilic esophagitis has been reported in patients receiving sublingual allergen immunotherapy.
If you develop persistent difficulty swallowing, chest pain associated with swallowing, or worsening heartburn during Oralair treatment, stop taking the medication and contact your healthcare provider.
Further evaluation may be necessary to determine whether eosinophilic esophagitis is present.
Do not take Oralair if you have a history of eosinophilic esophagitis. Stop treatment and seek medical assessment if you develop persistent swallowing difficulties, painful swallowing, or unexplained chest discomfort.Â
Before starting Oralair, provide your healthcare provider with a complete medical history.
This includes asthma, previous severe allergic reactions, eosinophilic esophagitis, significant cardiovascular disease, and any condition that may interfere with the management of anaphylaxis.
Your allergy specialist should also know about ongoing respiratory symptoms, mouth infections, dental problems, and other medical conditions that could affect treatment.
Oralair is intended for patients with a confirmed grass pollen allergy, typically established through allergy testing and a review of symptoms.
It should not be used to treat unrelated allergies, including food allergies, dust mite allergies, or pet allergies.
Patients receiving other immunotherapy treatments should tell their healthcare provider before starting Oralair.
Your healthcare provider will consider the severity of your symptoms, other medical conditions, and potential treatment risks before determining whether Oralair is appropriate.
Tell your healthcare provider about all existing medical conditions, previous allergic reactions, and ongoing allergy treatments before taking Oralair.
Oralair can help reduce seasonal grass pollen allergy symptoms, but it carries a risk of severe allergic reactions because it contains standardized grass pollen allergens.
The first dose must be administered under medical supervision, followed by at least 30 minutes of observation.
Patients with severe, unstable, or uncontrolled asthma, certain histories of serious allergic reactions, or eosinophilic esophagitis should not use Oralair.
Treatment should also be interrupted when significant mouth injuries or oral infections develop, and prolonged interruptions may require medically supervised restarting.
Seek emergency medical attention if you develop difficulty breathing, throat swelling, severe dizziness, fainting, or other symptoms of anaphylaxis. Do not take another Oralair dose after a serious reaction unless your allergy specialist explicitly instructs you to restart.
These precautions are not an exhaustive list of all possible warnings associated with Oralair. Always follow your allergy specialist’s instructions and prescribed emergency action plan.
Oralair should generally not be started during pregnancy because there is limited information about its safety in pregnant patients. Oralair contains standardized grass pollen extracts that gradually help the immune system become less sensitive to grass pollen allergens. Although this treatment can reduce seasonal allergy symptoms, it also carries a risk of severe allergic reactions, including anaphylaxis. Anaphylaxis is a potentially life-threatening allergic reaction that can cause difficulty breathing, swelling of the throat, and a sudden drop in blood pressure. During pregnancy, a severe allergic reaction may affect oxygen delivery and blood circulation, potentially putting both the mother and developing baby at risk. If you become pregnant while already taking Oralair, contact your allergy specialist. Your healthcare provider will evaluate how well you have tolerated treatment, the severity of your allergies, and whether continuing immunotherapy is appropriate. Do not start Oralair during pregnancy without specialist guidance. If you become pregnant while receiving treatment, consult your healthcare provider before taking further doses or making changes to your treatment plan.Â
The duration of Oralair treatment depends on the severity of your grass pollen allergy, your response to immunotherapy, and your healthcare provider’s recommendations. Oralair is generally started approximately four months before the expected beginning of grass pollen season. Treatment continues daily throughout the season to help the immune system become less sensitive to grass pollen allergens. For some adults, treatment may be repeated over three consecutive grass pollen seasons. Clinical studies have evaluated this approach, demonstrating that repeated seasonal treatment can provide meaningful improvements in allergy symptoms. However, Oralair does not necessarily require three years of treatment for every patient. The appropriate duration varies according to age, treatment response, and local prescribing recommendations. In Canada, clinical experience in adults is documented for up to three grass pollen seasons, while pediatric clinical experience is more limited. Your allergy specialist will evaluate your progress and determine whether treatment should continue in subsequent seasons. If no meaningful improvement occurs after the recommended treatment period, your healthcare provider may recommend discontinuing Oralair or considering another allergy management approach. Oralair is typically taken daily before and during grass pollen season. Treatment may be repeated over multiple seasons, but your allergy specialist will determine the appropriate duration based on your response.Â
Oralair sublingual tablets should be stored at room temperature in their original packaging to protect them from moisture and maintain their quality. According to Canadian prescribing information, Oralair should be stored at temperatures between 15°C and 30°C (59°F and 86°F). U.S. product labeling specifies controlled room temperature between 20°C and 25°C (68°F and 77°F), with permitted temporary temperature variations. Keep the tablets in their original sealed blister packs until you are ready to take a dose. Do not remove tablets in advance or transfer them into another container, as exposure to moisture may affect their stability. Store Oralair in a dry location away from excessive heat, direct sunlight, and humidity. Avoid keeping the medication in bathrooms or other areas where temperature and moisture levels frequently change. Always handle the tablets with clean, dry hands, and remove each tablet from its blister pack immediately before administration. Keep Oralair out of the sight and reach of children and pets to prevent accidental ingestion. Because the tablets contain allergens, accidental exposure may cause an allergic reaction in susceptible individuals. Do not use Oralair after its expiration date. If the tablets have been exposed to excessive moisture or stored improperly, ask your pharmacist whether they are still suitable for use. Store Oralair in its original sealed blister packaging at the temperature specified on your product label. Protect the tablets from moisture and keep them away from children and pets.Â
Yes. Oralair may be prescribed to children with confirmed grass pollen allergies who meet the applicable age and treatment requirements. In Canada, Oralair is approved for patients aged 5 to 50 years with moderate to severe seasonal grass pollen allergic rhinitis, with or without allergic conjunctivitis, who meet the additional prescribing criteria. In the United States, Oralair is approved for patients aged 5 to 65 years. The approved age range therefore depends on the country where the medication is prescribed. Children receiving Oralair should have their grass pollen allergy confirmed through appropriate testing and an assessment of their allergy symptoms. Treatment should be prescribed by a healthcare provider experienced in pediatric allergic diseases and allergen immunotherapy. Because Oralair contains grass pollen allergens, it may cause allergic reactions, including rare but potentially life-threatening anaphylaxis. The first dose must be administered in a healthcare setting under medical supervision, followed by at least 30 minutes of observation. After the first dose has been tolerated, subsequent doses may generally be taken at home under adult supervision. The dosage schedule may differ depending on the child’s age and local prescribing information. Caregivers should follow the specific instructions provided by the child’s allergy specialist. Children with severe, unstable, or uncontrolled asthma should not take Oralair. Caregivers must also understand how to recognize and respond to serious allergic reactions. Oralair may be used in eligible children aged five years and older, but treatment must be supervised by an experienced healthcare provider. Parents or caregivers should supervise home administration and follow the prescribed emergency action plan.Â
| Generic name: | Grass Pollen Extract |
|---|---|
| Formulation: | Sublingual Tablet |
| Strength(s): | 100IR, 300IR |
| Quantities Available: | 15, 90 |
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When ordering Oralair (grass pollen extract) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.
Here’s what you need to know:
Dosage and Quantity: Oralair is commonly prescribed in strengths of 100 IR or 300 IR, taken once daily. For a 90-day supply, this means you would order 90 tablets of either 100 IR or 300 IR (90 days x 1 tablet per day), depending on the strength prescribed by your healthcare provider.
No, we do not sell grass pollen extract directly on our website. However, you can still enjoy low prices on Oralair, which contains grass pollen extract as an active ingredient. To purchase Oralair, you will need a valid prescription from your healthcare provider. We require this to dispense the medication safely and appropriately. You can submit your prescription by mailing it to us, faxing it, or uploading it through your online account.
Yes, we ship Oralair (grass pollen extract) to both the United States and Puerto Rico.
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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Oralair (Grass Pollen Extract). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Oralair (Grass Pollen Extract).
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