Vetoryl (Trilostane)

Indications

Vetoryl is a medication used for the treatment of Cushing's syndrome (hyperadrenocorticism) in dogs. It contains trilostane, which is a competitive inhibitor of the enzyme 3-beta hydroxysteroid, which is involved in the synthesis of cortisol. By inhibiting this enzyme, Vetoryl helps to reduce the amount of cortisol produced by the adrenal glands, which can help alleviate the symptoms of Cushing's syndrome in dogs.

Vetoryl is a prescription-only medication and should only be used under the guidance and supervision of a veterinarian. Your vet will determine the appropriate dosage and duration of treatment based on your dog's individual needs and medical history.

Uses and Dosage

Vetoryl is given orally (by mouth) in the form of capsules. It should be given with food, and preferably in the morning if once daily dosing. This medication should take effect within 1 to 2 days. To use Vetoryl tablets, you should follow the guidance of your veterinarian, who will have prescribed the medication and provided you with instructions for use. The medication dosage will depend on the size and weight of your dog and their individual medical history.

Monitor your dog closely while they are taking Vetoryl and report any unusual symptoms, such as lethargy, anorexia, vomiting, and diarrhea, to your vet. Your dog will also need regular monitoring, including blood tests to check cortisol levels and kidney and liver function. This is to ensure the medication is working effectively and not harming your dog.

Side effect

Common Side Effects of Vetoryl (Trilostane):

• Diarrhea
• Lethargy/dullness
• Poor/reduced appetite
• Vomiting
• Weakness

Serious Side Effects of Vetoryl (Trilostane):

• Collapse
• Hemorrhagic diarrhea
• Hypoadrenocortical crisis or adrenal necrosis/rupture (may result in death)
• Severe depression

Form and strength

Vetoryl (Trilostane) is available in the following forms and strength:

Vetoryl: Capsule

• 30 mg

Caution

• Vetoryl can cause a range of side effects in some dogs, including lethargy, anorexia, vomiting, and diarrhea. Monitor your dog closely while they are taking Vetoryl and report any unusual symptoms to your vet.
• Dosage must be carefully adjusted based on your dog's individual response to the medication, and it may need to be adjusted over time as your dog's condition changes.
• Vetoryl may not be suitable for all dogs, including pregnant or lactating dogs or dogs with liver or kidney disease. Your vet will advise you if Vetoryl is appropriate for your dog's specific circumstances.
• Dogs taking Vetoryl will need regular monitoring, including blood tests to check cortisol levels and kidney and liver function. This is to ensure the medication is working effectively and not harming your dog.
• Vetoryl may interact with other medications your dog is taking, including potassium-sparing diuretics and non-steroidal anti-inflammatory drugs (NSAIDs).
• Administering an incorrect dose of Vetoryl can be dangerous for your dog and may cause over- or under-dosing, which can have adverse effects on their health.
• Long-term use of Vetoryl may have adverse effects on the function of your dog's adrenal glands. Regular monitoring is essential in minimizing these risks.
• Comply with your vet's instructions regarding the administration of Vetoryl. Failing to do so may not only worsen your dog's health but also render the medication ineffective.

Frequently Asked Questions (FAQ)

When is the best time to give a dog Vetoryl?

We recommend that you give your dog Vetoryl with a meal in the morning, as this will make it easier for your veterinary surgeon to perform monitoring tests 4-6 hours after dosing.

How long does it take for Vetoryl to get out of a dog's system?

In healthy dogs, maximal plasma levels of trilostane occur within 1.5 hours, returning to baseline levels within twelve hours, although large inter-dog variation occurs. There is no accumulation of trilostane or its metabolites over time.

Is Vetoryl suitable for all dogs?

Vetoryl may not be suitable for all dogs, including pregnant or lactating dogs or dogs with liver or kidney disease. Your vet will advise you if Vetoryl is appropriate for your dog's specific circumstances.

How often do I need to take my dog to the vet while they are taking Vetoryl?

Dogs taking Vetoryl will need regular monitoring, including blood tests to check cortisol levels and kidney and liver function. This is to ensure the medication is working effectively and not harming your dog.

 Resources

• https://www.drugs.com/pro/vetoryl.html
• https://www.dechra-us.com/our-products/us/companion-animal/dog/prescription/vetoryl-capsules-trilostane
• https://vcahospitals.com/shop/product/vetoryl-trilostane-capsules
• https://www.petmd.com/pet-medication/vetoryl
• https://www.vetrxdirect.com/product/view/vetoryl-trilostane-for-dogs-rx
• https://shop.banfield.com/vetoryl-trilostane-capsules.html