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Renvela

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Prescription Prescription Required FormationFormulation: Tablet

Sevelamer Carbonate

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Renvela contains the active ingredient sevelamer carbonate. It is a prescription medication used to lower high phosphorus levels in people with chronic kidney disease who are receiving dialysis.

Why phosphorus levels rise in kidney disease

Phosphorus is a mineral found in many foods, including dairy products, meat, beans, nuts, whole grains, processed foods, and dark-coloured soft drinks. Your body needs some phosphorus to support healthy bones, cells, and energy production.

Healthy kidneys remove extra phosphorus from the blood. When the kidneys are severely damaged, they may no longer remove enough phosphorus, even with dialysis. This can cause the phosphorus level in your blood to become too high. This condition is called hyperphosphatemia.

Why high phosphorus is a concern

High phosphorus levels may not cause noticeable symptoms at first. Over time, however, excess phosphorus can disturb the balance of calcium and other minerals in your body.

This may lead to:

  • Weak or painful bones
  • A higher risk of fractures
  • Itchy skin
  • Muscle cramps
  • Abnormal activity of the parathyroid glands
  • Calcium deposits in blood vessels and soft tissues
  • A higher risk of heart and circulation problems

Keeping phosphorus within the recommended range is an important part of managing chronic kidney disease.

How Renvela works

Renvela belongs to a group of medications called phosphate binders. It works inside your stomach and intestines rather than entering your bloodstream.

When you take Renvela with a meal, it attaches to phosphorus in the food you eat. This prevents some of the phosphorus from being absorbed into your blood.

The medication and the phosphorus it binds to then leave your body through your stool.

Why Renvela must be taken with meals

Renvela only works when phosphorus from food is present in your digestive tract. For this reason, it should be taken with meals and sometimes with snacks, depending on your prescription.

Taking it without food will not provide the same benefit because there may be little or no dietary phosphorus available for the medication to bind.

Your healthcare provider may give you a different dose for larger and smaller meals based on how much phosphorus they contain.

What Renvela does not do

Renvela does not remove phosphorus that is already circulating in your blood. It helps prevent additional phosphorus from being absorbed from food.

It also does not replace dialysis, dietary changes, or other treatments recommended by your kidney-care team.

Renvela does not contain calcium or metal. This may make it a suitable option for some patients who need to avoid extra calcium from calcium-based phosphate binders.

Using Renvela as part of your kidney-care plan

Renvela is usually used as part of a broader treatment plan that may include:

  • Regular dialysis
  • A diet lower in phosphorus
  • Reading food labels for phosphate additives
  • Limiting processed and packaged foods
  • Taking vitamin D or other prescribed medications
  • Regular blood tests

Your kidney dietitian can help you identify foods that are high in phosphorus and suggest lower-phosphorus alternatives.

Monitoring during treatment

Your healthcare provider will order regular blood tests to check your phosphorus level and determine whether your dose needs to be changed.

They may also monitor your calcium, bicarbonate, and parathyroid hormone levels. These results help your healthcare team assess your overall mineral and bone health.

You will not usually feel Renvela working. Blood tests are the main way to confirm that the medication is controlling your phosphorus level.

Important treatment reminders

Take Renvela exactly as prescribed and with the meals or snacks specified by your healthcare provider. Do not increase, reduce, or skip doses based only on how you feel.

Swallow the tablets whole unless your pharmacist or healthcare provider gives you different instructions. Renvela is also available as a powder that is mixed with water.

Tell your healthcare provider if you have difficulty swallowing, severe constipation, abdominal pain, vomiting, or trouble passing stool. Renvela can cause digestive side effects and may not be appropriate for people with certain bowel conditions.

Continue following your dialysis schedule and kidney-friendly diet while taking Renvela. Attend all recommended blood tests and follow-up appointments so your healthcare provider can confirm that your phosphorus level remains within a safe range.

Renvela contains the active ingredient sevelamer carbonate. It is a prescription phosphate binder used to control high phosphorus levels in adults and children aged 6 years and older who have chronic kidney disease and are receiving dialysis.

Healthy kidneys remove excess phosphorus from the blood. When the kidneys are not working properly, phosphorus can build up and contribute to weak bones, itching, and calcium deposits in the blood vessels and other tissues.

Renvela works inside the digestive tract by binding to phosphorus from food. This prevents some of the phosphorus from being absorbed into the bloodstream. The bound phosphorus then leaves the body through the stool.

Renvela must be taken with meals because it needs to be present in the digestive tract at the same time as the phosphorus in food.

Adult dosage

For adults who are not already taking a phosphate binder, the starting dose depends on the phosphorus level shown in blood tests:

  • Phosphorus above 5.5 but below 7.5 mg/dL: 800 mg three times daily with meals
  • Phosphorus of 7.5 mg/dL or higher: 1,600 mg three times daily with meals

Your healthcare provider may increase or decrease the dose based on regular phosphorus blood tests. Adult doses are generally adjusted by 800 mg with each meal at intervals of approximately two weeks until the phosphorus level reaches the recommended range.

The average adult dose used in clinical studies was approximately 7.2 grams per day, divided among meals. However, your dose may be lower or higher depending on your phosphorus level and response to treatment.

Dosage for children

Renvela may be used in children aged 6 years and older who have chronic kidney disease and are receiving dialysis.

The starting dose is based on body surface area, which is calculated from the child’s height and weight:

  • Body surface area from 0.75 to less than 1.2 m²: 800 mg with each meal
  • Body surface area of 1.2 m² or greater: 1,600 mg with each meal

The child’s healthcare provider may adjust the dose every two weeks based on phosphorus blood tests and body size.

Renvela has not been adequately studied in children younger than 6 years.

Available forms

Renvela is available as:

  • An 800 mg tablet
  • An 800 mg powder packet
  • A 2,400 mg powder packet

Swallow the tablets whole unless your healthcare provider gives you different instructions. The powder should be mixed with water or a small amount of food or drink and consumed within 30 minutes. Do not heat the powder mixture.

Important dosing reminders

Take Renvela with every meal included in your prescription. Taking it without food will not effectively bind dietary phosphorus.

Do not increase, reduce, or skip doses based only on how you feel. High phosphorus often causes no noticeable symptoms, so blood tests are needed to determine whether the medication is working.

Your healthcare provider may adjust your dose based on your phosphorus level, meal size, dietary phosphorus intake, and response to treatment.

Common Side Effects of Renvela (Sevelamer Carbonate):

  • Nausea
  • Vomiting
  • Diarrhea
  • Indigestion
  • Stomach pain
  • Gas
  • Constipation

Serious Side Effects of Renvela (Sevelamer Carbonate):

  • Difficulty swallowing
  • Vitamin and nutrient deficiencies
  • Low bicarbonate levels
  • Severe abdominal pain
  • Persistent vomiting
  • Severe constipation
  • A swollen abdomen
  • Bloody stools
  • Black or tarry stools
  • Allergic reaction
    • Rash
    • Itching
    • Hives
    • Swelling of the face, lips, tongue, or throat
    • Difficulty breathing or swallowing

Renvela (Sevelamer Carbonate) is available in the following forms and strength:

Renvela: Tablet

  • 800 mg

Sevelamer Carbonate: Tablet

  • 800 mg

Renvela can be an effective treatment for high phosphorus levels, but it may not be suitable for everyone. Tell your healthcare provider about your medical conditions, medications, diet, and any digestive symptoms before starting treatment.

Bowel obstruction

Do not take Renvela if you have a bowel obstruction. A bowel obstruction prevents food, fluid, or stool from moving normally through the intestines and can become a medical emergency.

Seek immediate medical attention if you develop severe abdominal pain, a swollen abdomen, persistent vomiting, or an inability to pass stool or gas.

Digestive disorders

Use Renvela cautiously if you have severe constipation, difficulty swallowing, swallowing disorders, major digestive-tract surgery, slow movement of the stomach or intestines, or another serious bowel condition.

Renvela has been associated with uncommon but serious digestive complications, including intestinal blockage, severe constipation, ulcers, bleeding, inflammation, and damage to the intestinal wall. Contact your healthcare provider promptly if you develop persistent constipation, worsening stomach pain, vomiting, abdominal swelling, or blood in your stool.

Difficulty swallowing the tablets

Renvela tablets are relatively large and may become lodged in the throat or esophagus, particularly in people who already have difficulty swallowing.

Tell your healthcare provider if you have swallowing problems. Renvela powder for oral suspension may be a safer or easier option. Seek urgent care if a tablet becomes stuck or you develop choking, chest discomfort, or difficulty breathing.

Medication interactions

Renvela can reduce the absorption of certain oral medications because it binds substances inside the digestive tract. Tell your healthcare provider and pharmacist about every prescription medication, over-the-counter product, vitamin, and supplement you take.

Some medications may need to be taken at least one hour before or three hours after Renvela. The appropriate timing depends on the medication and how important consistent absorption is. Do not change your medication schedule without guidance from your healthcare provider or pharmacist.

Vitamin deficiencies

Renvela may reduce the absorption of fat-soluble vitamins, including vitamins A, D, E, and K, as well as folic acid. People receiving dialysis may already have an increased risk of vitamin deficiencies.

Your healthcare provider may monitor your vitamin levels or recommend a kidney-specific vitamin supplement. Do not take vitamins or minerals without checking with your kidney-care team because some supplements may contain phosphorus, potassium, calcium, or other ingredients that need to be limited.

Low bicarbonate and metabolic acidosis

People with chronic kidney disease may develop low bicarbonate levels, which can contribute to metabolic acidosis. Your healthcare provider may periodically check your bicarbonate level and other blood chemistry results while you take Renvela.

Attend all scheduled blood tests so your healthcare team can monitor your phosphorus, calcium, bicarbonate, and parathyroid hormone levels.

Allergic reactions

Do not take Renvela if you have had an allergic reaction to sevelamer carbonate, sevelamer hydrochloride, or any ingredient in the medication.

Seek emergency medical attention if you develop hives, severe itching, swelling of your face, lips, tongue, or throat, or difficulty breathing or swallowing.

Pregnancy and breastfeeding

Tell your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. Renvela is not absorbed significantly into the bloodstream, but it may reduce the absorption of vitamins and nutrients that are important during pregnancy.

Your healthcare provider will determine whether the benefits of treatment outweigh any possible risks and may recommend closer nutritional monitoring.

Children

Renvela may be used in children aged 6 years and older with chronic kidney disease who are receiving dialysis. Its safety and effectiveness have not been established in children younger than 6 years.

Children should receive a dose based on their body size and phosphorus level and should be monitored regularly by a pediatric kidney specialist.

Taking Renvela safely

Take Renvela with meals exactly as prescribed. Do not crush or chew the tablets. Use the powder formulation if directed, and prepare it according to the instructions provided.

Tell your healthcare provider if you miss meals, change your diet, have trouble swallowing, or develop ongoing constipation. Do not stop taking Renvela or adjust your dose without medical guidance, even if you feel well, because high phosphorus often causes no noticeable symptoms.

When should I take Renvela?

Take Renvela with meals, exactly as prescribed. It needs to be present in your digestive tract at the same time as the phosphorus in your food. Your healthcare provider may prescribe a different number of tablets or powder packets with each meal, depending on your phosphorus level and the amount of phosphorus in your diet.

Can I take Renvela without food?

Renvela should generally not be taken without food because there may be little or no dietary phosphorus for it to bind. Follow the instructions given by your kidney-care team, especially if you skip a meal.

How long does Renvela take to work?

Renvela begins binding phosphorus when it is taken with food, but you will not usually feel it working. Blood tests are needed to determine whether your phosphorus level is improving. Your healthcare provider may adjust the dose approximately every two weeks until your phosphorus level reaches the desired range.

How do I know whether Renvela is working?

Regular blood tests are the main way to determine whether Renvela is working. Your healthcare provider will monitor your phosphorus level and may also check calcium, bicarbonate, and parathyroid hormone levels.

What should I do if I miss a dose?

If you miss a dose with a meal, skip the missed dose and take your usual dose with your next meal. Do not take an extra dose or double your next dose to make up for the missed one. Contact your pharmacist or healthcare provider if you are unsure what to do.

Can Renvela tablets be crushed or chewed?

Renvela tablets should be swallowed whole. Do not crush, chew, or break them. Tell your healthcare provider if the tablets are difficult to swallow. Renvela is also available as a powder for oral suspension, which may be easier for some patients.

Can Renvela cause constipation?

Yes. Renvela can cause or worsen constipation. Rarely, it may contribute to serious intestinal problems. Contact your healthcare provider promptly if you experience severe constipation, worsening abdominal pain, vomiting, abdominal swelling, blood in your stool, or an inability to pass stool or gas.

Who should not take Renvela?

Do not take Renvela if you have a bowel obstruction or if you are allergic to sevelamer carbonate or any ingredient in the medication. Tell your healthcare provider if you have severe constipation, swallowing difficulties, major digestive-tract surgery, slow intestinal movement, or another serious bowel condition.

Can Renvela interact with other medications?

Yes. Renvela may reduce the absorption of certain oral medications by binding to them in the digestive tract. Some medications may need to be taken at least one hour before or three hours after Renvela. The correct timing depends on the medication, so ask your healthcare provider or pharmacist before changing your schedule.

Can I take vitamins with Renvela?

Renvela may reduce the absorption of certain vitamins, including vitamins A, D, E, and K and folic acid. Your healthcare provider may recommend a kidney-specific vitamin supplement. Do not begin taking vitamins, minerals, or herbal supplements without checking with your kidney-care team.

Does Renvela contain calcium?

No. Renvela is a calcium-free phosphate binder. It may be prescribed when a healthcare provider wants to control phosphorus without adding extra calcium.

Is Renvela the same as Renagel?

No, but the medications are closely related. Renvela contains sevelamer carbonate, while Renagel contains sevelamer hydrochloride. Both medications lower phosphorus by binding it in the digestive tract, but they contain different salt forms. Do not switch between them unless your healthcare provider instructs you to do so.

Can Renvela be used during pregnancy or breastfeeding?

Tell your healthcare provider if you are pregnant, planning a pregnancy, or breastfeeding. Renvela is not significantly absorbed into the bloodstream, but it may affect the absorption of vitamins and nutrients. Your healthcare provider will determine whether it is appropriate and whether additional nutritional monitoring is needed.

Can children take Renvela?

Renvela is approved for children aged 6 years and older who have chronic kidney disease and are receiving dialysis. The dose is based on the child’s body size, phosphorus level, and response to treatment.

How long will I need to take Renvela?

Renvela may be required for as long as your kidneys cannot adequately control phosphorus and your healthcare provider determines that treatment is necessary. Do not stop taking it because you feel well. High phosphorus often causes no obvious symptoms, and stopping treatment may allow the level to rise again.

Does Renvela replace a low-phosphorus diet or dialysis?

No. Renvela is used together with dialysis and a kidney-friendly diet. It does not replace either one. Continue following the dietary recommendations provided by your kidney-care team and attend all scheduled dialysis sessions and blood tests.

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Additional Information Book
Generic name:

Sevelamer Carbonate

Formulation:

Tablet

Strength(s):

800mg

Quantities Available:

100, 180, 200, 360

Why customers love Online Pharmacies Canada

Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.

Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.

How to Order

How much Renvela can I order at once from a Canadian pharmacy?

When ordering Renvela (sevelamer carbonate) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is beneficial for managing chronic conditions without frequent refills.

Here’s what you need to know:

Dosage and Quantity: Renvela is commonly prescribed in dosage of 800 mg tablets, taken multiple times daily with meals to control serum phosphorus levels in patients with CKD.

For example, if prescribed 800 mg three times daily, for a 90-day supply, you would order 270 tablets (90 days x 3 tablets per day).

Do you sell sevelamer carbonate?

Yes, we sell sevelamer carbonate on our website, and you can enjoy low prices. To purchase sevelamer carbonate, you will need a valid prescription from your healthcare provider. We require this to dispense the medication. You can conveniently submit your prescription by mail, fax, or upload it through your online account to facilitate the ordering process.

Do you offer shipping of Renvela (sevelamer carbonate) to the United States?

Yes, we ship Renvela (sevelamer carbonate) to both the United States and Puerto Rico.

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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Renvela (Sevelamer Carbonate). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Renvela (Sevelamer Carbonate).