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Renagel contains the active ingredient sevelamer. It is a prescription phosphate-binding medication used to help control high phosphorus levels in people with chronic kidney disease (CKD) who are receiving dialysis.
Renagel is used to treat hyperphosphatemia, which means there is too much phosphorus in the blood.
Phosphorus is a mineral found naturally in many foods. Healthy kidneys normally remove extra phosphorus from the bloodstream and pass it out of the body in urine. When kidney function becomes severely reduced, the kidneys may no longer be able to remove enough phosphorus.
As a result, phosphorus can build up in the blood. This is especially common in people with advanced chronic kidney disease who require hemodialysis or peritoneal dialysis.
When phosphorus levels remain too high, the body may pull calcium from the bones. Over time, this can weaken bones and contribute to bone pain or fractures.
High phosphorus levels can also disturb the balance between phosphorus, calcium, and parathyroid hormone. These changes may contribute to mineral and bone disorders associated with chronic kidney disease.
Excess phosphorus and calcium may also contribute to calcium deposits in blood vessels and other tissues. Keeping phosphorus levels within the recommended range is therefore an important part of long-term kidney disease management.
Renagel belongs to a class of medications called phosphate binders.
Sevelamer works inside the digestive tract. When Renagel is taken with food, it binds to phosphorus from the meal before that phosphorus can be absorbed into the bloodstream.
The bound phosphorus remains in the digestive tract and leaves the body in the stool.
Because sevelamer is not significantly absorbed into the bloodstream, its main effect takes place in the gastrointestinal tract.
Renagel should be taken with meals because this is when phosphorus from food enters the digestive tract.
Taking the medication with food allows it to bind to dietary phosphorus more effectively. Taking Renagel without a meal provides less opportunity for the medication to bind phosphorus.
Your healthcare provider may adjust the dose based on your blood phosphorus levels and the amount of phosphorus in your diet.
Renagel does not contain calcium or aluminum.
This can be useful for some patients who need phosphorus control without adding extra calcium to the body. Your healthcare provider will decide which phosphate binder is most appropriate based on your calcium levels, phosphorus levels, other medical conditions, and overall treatment plan.
Dialysis helps remove some excess phosphorus from the blood, but it may not remove enough phosphorus on its own.
Renagel can be used together with dialysis and a phosphorus-controlled diet to help keep phosphorus levels within the target range.
Treatment may include:
Your healthcare provider may regularly check your blood phosphorus levels to determine how well Renagel is working.
Other laboratory tests may also be used to monitor calcium, parathyroid hormone, bicarbonate, and other measurements related to kidney and bone health.
Your Renagel dose may be adjusted over time depending on your blood test results, diet, dialysis treatment, and response to therapy.
Renagel helps control phosphorus while you are taking it, but it does not cure chronic kidney disease.
Phosphorus levels may rise again if treatment is stopped or if phosphorus intake increases. For this reason, take Renagel consistently with meals and continue treatment for as long as your healthcare provider recommends.
Renagel should be taken with meals because it needs to be present in the digestive tract when phosphorus from food is available.
The tablets should be taken exactly as prescribed by your healthcare provider. The dose is based mainly on your blood phosphorus level and may be adjusted over time according to laboratory results.
For patients who are not already taking another phosphate binder, the usual starting dose is 800 mg to 1,600 mg with each meal, generally taken three times daily.
Typical starting doses are:
Your healthcare provider may adjust your Renagel dose based on your blood phosphorus level.
The dose can generally be increased or decreased by one tablet per meal at approximately 2-week intervals until phosphorus levels are within the desired range.
Regular blood tests are important because the amount of Renagel you need may change depending on your phosphorus levels, diet, dialysis treatment, and response to therapy.
Take Renagel with meals and follow any phosphorus-controlled diet recommended by your healthcare provider.
Do not change your dose or stop taking Renagel without speaking with your healthcare provider. Renagel helps control phosphorus while you are taking it, but it does not cure chronic kidney disease.
Renagel (Sevelamer) is available in the following forms and strength:
Do not use Renagel if you have a bowel obstruction.
Sevelamer can cause or worsen serious gastrointestinal problems. Seek medical attention if you develop severe abdominal pain, persistent vomiting, severe constipation, abdominal swelling, or an inability to pass stool or gas.
Use Renagel with caution if you have:
Cases of tablets becoming stuck in the esophagus, bowel obstruction, gastrointestinal bleeding, ulcers, colitis, tissue damage, and intestinal perforation have been reported with sevelamer. Some cases required hospitalization or surgery.
Do not take Renagel if you are allergic to sevelamer hydrochloride or any ingredient in the medication.
Seek urgent medical attention if you develop signs of a serious allergic reaction, such as swelling of the face, lips, tongue, or throat, severe rash, or difficulty breathing.
Long-term treatment with sevelamer may affect the absorption or levels of certain nutrients.
Your healthcare provider may monitor vitamins D, E, and K, as well as folic acid, particularly during long-term treatment. Vitamin supplements may be recommended if needed.
Renagel contains sevelamer hydrochloride, which can affect the body’s acid-base balance.
Your healthcare provider may monitor bicarbonate and chloride levels during treatment, especially if you use Renagel for a long period.
Renagel can bind to some medications in the digestive tract and reduce how much of them your body absorbs.
Tell your healthcare provider about all prescription medications, over-the-counter products, vitamins, and supplements you take. Some medications may need to be taken at a different time from Renagel or monitored more closely.
This is particularly important for medications where even a small reduction in absorption could affect their safety or effectiveness.
Renagel may cause constipation, and severe constipation can increase the risk of bowel complications.
Contact your healthcare provider if constipation becomes persistent, severe, or is accompanied by abdominal pain, vomiting, or swelling.
Your healthcare provider will usually monitor your blood phosphorus level to determine how well Renagel is working.
Other laboratory tests may include calcium, bicarbonate, chloride, vitamin levels, and other measurements related to chronic kidney disease and dialysis. Your Renagel dose may be adjusted based on these results.
Renagel is intended to be taken with meals because it works by binding phosphorus from food. Follow your healthcare provider’s instructions about which meals require a dose and how much to take.
Renagel begins binding phosphorus in the digestive tract when it is taken with a meal. However, your healthcare provider will use blood tests to determine how well your phosphorus level is being controlled and whether your dose needs to be adjusted.
The length of treatment depends on your kidney function, dialysis treatment, diet, and phosphorus levels. Some patients may need phosphate-binding treatment for a long period. Continue taking Renagel for as long as your healthcare provider recommends. Do not stop treatment or change the dose on your own.
Because Renagel is taken with meals, a missed dose is generally not made up by taking extra tablets later. If you miss a dose with a meal, follow the instructions provided by your healthcare provider or pharmacist, and do not double your next dose.
Yes. Renagel may bind to certain medications in the digestive tract and reduce how much of them your body absorbs. Some medications may need to be taken at a different time from Renagel. For medications where reduced absorption could have an important effect, your healthcare provider may recommend separating the doses or monitoring the medication more closely. Sevelamer is known to reduce the absorption of some drugs, including ciprofloxacin and mycophenolate mofetil.
Yes. Constipation is a known side effect of Renagel. Severe or worsening constipation should be reported to your healthcare provider because, in rare cases, sevelamer has been associated with serious bowel complications such as fecal impaction, bowel obstruction, or perforation.
No. Renagel is a calcium-free phosphate binder. Its active ingredient is sevelamer hydrochloride, so it can lower phosphorus without adding extra calcium to the body.
No. Renagel does not cure chronic kidney disease or replace dialysis. It is used as part of a treatment plan to help control phosphorus levels. Treatment may also include dialysis, dietary phosphorus restriction, and regular blood tests.
Yes. Long-term treatment with sevelamer may reduce the absorption of certain vitamins and nutrients, including vitamins D, E, and K and folic acid. Your healthcare provider may monitor these levels and recommend supplements if needed.
Store Renagel at controlled room temperature, generally around 25°C (77°F), with permitted short-term temperatures between 15°C and 30°C (59°F to 86°F). Keep the tablets protected from moisture and do not use them after the expiration date on the bottle.
| Generic name: | Sevelamer, Sevelamer Hydrochloride |
|---|---|
| Formulation: | Tablet |
| Strength(s): | 400mg, 800mg |
| Quantities Available: | 90, 100, 180 |
Our online Canadian Pharmacy is known for high standards of quality, safety, and efficiency when it comes to medications.
Our pharmacy offers lower prices on prescription drugs compared to traditional pharmacies.
When ordering Renagel (sevelamer) from a Canadian pharmacy, you can typically purchase up to a 90-day supply at one time, which is common for prescription medications to ensure adequate management of chronic conditions without frequent refills.
Here’s what you need to know:
Dosage and Quantity: Renagel is commonly prescribed at a dosage of 800 mg, taken three times daily with meals. For a 90-day supply, this means you would order 270 tablets (90 days x 3 tablets per day).
Yes, we sell sevelamer on our website. You can enjoy low prices when you order through us. To purchase sevelamer, you will need a valid prescription from your healthcare provider. We require this prescription to dispense the medication safely and appropriately. You have the option to submit your prescription by mailing it to us, faxing it, or uploading it through your online account.
Yes, we ship Renagel (sevelamer) to both the United States and Puerto Rico.
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Online Pharmacies Canada has provided information from third parties intended to increase awareness and does not contain all the information about Renagel (Sevelamer). Talk to your doctor or other qualified medical practitioners for medical attention or advice, or if you have any concerns about Renagel (Sevelamer).
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