Asthma-Related Death
Serevent Diskus contains salmeterol, a long-acting beta-2 adrenergic agonist (LABA).
When a LABA is used by itself without an inhaled corticosteroid (ICS) to treat asthma, it can increase the risk of serious asthma-related complications, including asthma-related death.
For this reason, Serevent Diskus should only be used for asthma together with an inhaled corticosteroid. It should generally be added only when asthma is not adequately controlled with an ICS alone.
Not for Sudden Asthma or COPD Attacks
Serevent Diskus is a long-acting maintenance medication and should not be used to treat sudden wheezing, shortness of breath, or an acute asthma or COPD attack.
Use the fast-acting rescue inhaler prescribed by your healthcare provider for sudden breathing symptoms.
Seek medical attention if your breathing suddenly becomes worse or if your rescue inhaler is not working as well as usual.
Worsening Asthma or COPD
Do not start Serevent Diskus during a rapidly worsening or potentially life-threatening episode of asthma or COPD.
Contact your healthcare provider if you notice:
- Increasing wheezing
- More frequent coughing
- Increased shortness of breath
- A greater need for your rescue inhaler
- Reduced effectiveness of your usual rescue medication
These may be signs that your condition is not adequately controlled.
Sudden Breathing Problems
In rare cases, Serevent Diskus can cause paradoxical bronchospasm, which means breathing suddenly becomes worse immediately after using the medication.
This can cause severe wheezing or difficulty breathing and may be life-threatening.
If this happens, stop using Serevent Diskus and use your fast-acting rescue inhaler as directed. Seek medical attention promptly.
Serious Allergic Reactions
Serious allergic reactions can occur with Serevent Diskus.
Seek immediate medical attention if you develop:
- Hives or a severe rash
- Swelling of the face, lips, tongue, or throat
- Difficulty breathing or swallowing
Serevent Diskus contains lactose that may contain small amounts of milk protein and should not be used by people with a severe allergy to milk proteins.
Heart and Blood Pressure Effects
Salmeterol can affect the cardiovascular system.
Some people may experience:
- Faster heartbeat
- Palpitations
- Changes in blood pressure
- Abnormal heart rhythms
- Chest discomfort
Tell your healthcare provider if you have heart disease, high blood pressure, or an irregular heartbeat before using Serevent Diskus.
Seek medical attention if you develop significant chest pain, a very fast or irregular heartbeat, fainting, or other concerning cardiovascular symptoms.
Low Potassium or High Blood Sugar
Beta-2 agonists such as salmeterol can sometimes lower blood potassium levels or increase blood glucose levels.
Tell your healthcare provider if you have diabetes or a condition that affects your potassium levels.
Certain medications, including some diuretics, may increase the risk of low potassium when taken with Serevent Diskus.
Drug Interactions
Serevent Diskus can interact with other medications.
Tell your healthcare provider about all prescription medications, over-the-counter products, vitamins, and herbal supplements you use.
Important interactions may occur with certain:
- Beta-blockers
- Monoamine oxidase inhibitors (MAOIs)
- Tricyclic antidepressants
- Diuretics
- Medications that strongly affect how salmeterol is broken down in the body
Some combinations may increase the risk of cardiovascular effects or other serious side effects.
Pregnancy
Available human data have not identified a clear increased risk of major birth defects, miscarriage, or other adverse pregnancy outcomes with Serevent Diskus.
However, asthma itself can pose risks during pregnancy if it is not well controlled.
Tell your healthcare provider if you are pregnant or planning to become pregnant. Your healthcare provider will weigh the benefits of maintaining good asthma control against any potential medication risks.
Breastfeeding
It is not known whether salmeterol passes into human breast milk.
Because blood levels after inhaled doses are low, the amount that could enter breast milk is also expected to be low.
Your healthcare provider will consider the benefits of breastfeeding, your need for Serevent Diskus, and any potential risks to the nursing infant.
Use in Children
Serevent Diskus may be used for asthma in children 4 years of age and older, but it must be used together with an inhaled corticosteroid.
The safety and effectiveness of Serevent Diskus have not been established in children younger than 4 years.
In children and adolescents with asthma who require both an ICS and a LABA, a combination inhaler containing both medications is often preferred to help ensure that both treatments are taken together.
Other Medical Conditions
Tell your healthcare provider before using Serevent Diskus if you have:
- Heart disease
- High blood pressure
- Seizures
- Thyroid problems
- Diabetes
- Liver problems
- A severe milk protein allergy
These conditions may affect whether Serevent Diskus is appropriate or whether additional monitoring is needed.
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