Trazodone comes in the form of an oral tablet and is usually prescribed to be taken once or twice daily, depending on the advice of your doctor. The tablet should be taken with a meal or snack, and it is best to take it at bedtime. When taking the tablet, it should be swallowed whole with a glass of water.
The recommended dosage of Trazodone to start is 150 mg per day, divided into two or more doses. This dose can be increased gradually by 50 mg every 3-4 days, considering the patient’s response and any signs of intolerance. If drowsiness is experienced, it is recommended to give most of the daily dose at bedtime or reduce it.
For outpatients, the maximum daily dose should not exceed 400 mg, while inpatients (severely depressed patients) may receive up to 600 mg per day in divided doses. Once an adequate response is achieved, the dosage should be gradually reduced, and further adjustments should be based on the patient’s therapeutic response.
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