How does it work?

Cilazapril belongs to a group of medicines called ACE inhibitors. It blocks the action of a chemical in the body called angiotensin converting enzyme. Normally, this chemical produces another chemical, angiotensin II. Thus cilazapril reduces the amount of angiotensin II which has two actions. Firstly it acts on the blood vessels to make them narrow and secondly it acts on the kidney to produce less urine. As cilazapril stops the production of angiotensin II, these actions are reversed. Therefore more urine is produced by the kidneys, which results in less fluid in the blood vessels. The blood vessels also widen. The overall effect of this is a drop in blood pressure and a decrease in the workload of the heart.

What is cilazapril used for?

  • Heart failure
  • High blood pressure

Use with caution in

  • dehydration
  • history of swelling of the lips, face or tongue (angioedema)
  • kidney disease
  • narrowing of blood vessels in the extremities
  • people on a low sodium diet

Not to be used if

  • You are allergic to any of the active ingredients
  • You have disease of the blood vessels in the kidney (renovascular disease)
  • You have fluid collection in abdomen (ascites)
  • You have narrowing of the main artery of the body (aortic stenosis)
  • You are pregnant, planning to become pregnant, or breast feeding

Side effects of cilazapril

  • rash
  • diarrhoea, constipation, nausea, vomiting or abdominal pain
  • dry cough
  • severe swelling of lips, face or tongue
  • dizziness
  • alteration in taste
  • difficulty in breathing due to narrowing of the airways
  • disorders of the blood, kidney or liver

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