Alendronate Sodium Information

Alendronate Sodium (Fosamax) is used for the treatment of osteoporosis in postmenopausal women. It is also used to increase bone mass in men with osteoporosis caused by steroid medications (prednisone). It reduces the chance of having a hip or spinal fracture. Alendronate sodium is also helpful in the treatment of Paget’s disease of the bone.

Important Information

Alendronate Sodium is not a hormone. This medicine may cause problems in your esophagus such as inflammation, ulcers, bleeding, and in rare cases, blockage or perforation. It is not recommended for patients with significant kidney conditions. It can lower blood calcium.

Not to be taken if you

  • Have problems with your esophagus (tube that connects your mouth with your stomach)
  • Have the inability to stand/sit upright for at least 30 minutes
  • Have low levels of calcium in your blood
  • Are allergic to Alendronate Sodium or any of its ingredients
  • Are pregnant, planning to become pregnant, or breastfeeding.


Always take you medicine exactly as prescribed by your doctor.

Take each tablet first thing in the morning with a full glass of water (6 to 8 oz), at least 30 minutes before the first food, beverage or medication of the day. Taking this medicine with orange juice or coffee can decrease its effectiveness.

Do not chew or suck on the tablet. After taking this medicine, remain upright (sitting/standing) for 30 minutes. Do not lie down until after eating. Do not take at bedtime. Do not take at the same time as other medicines (including aspirin), antacids or calcium supplements. Wait at least one-half hour before taking any other drug. If a dose is missed, do not take it later in the day. The next day, continue your usual schedule of 1 tablet once a day.

Alendronate Side Effects

Most severe: Abdominal pain, bone and joint pain, constipation, diarrhea, indigestion, muscle pain, nausea.

Most common: Abdominal distention, acid backup, difficulty in swallowing, esophageal ulcers, gas, headache, stomach ulcers, vomiting.

Other: Changes in taste, esophageal blockage or perforation, eye pain, hives, inflammation of the stomach, mouth sores, muscle cramps, rash, skin redness, swollen face and throat.

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Information provided on this website is for general purposes only. It is not intended to take the place of advice from your practitioner