Table of contents:
Indications
Lofibra is a medication used in the treatment of elevated levels of cholesterol and triglycerides in the blood. The active ingredient in Lofibra is fenofibrate, which belongs to a group of drugs called fibrates. It works by increasing the enzyme that breaks down fats in the blood, thereby lowering "bad" cholesterol (such as LDL) and triglycerides while increasing "good" cholesterol (HDL).
Lofibra can be used as an adjunct to diet for the treatment of primary hypercholesterolemia or mixed hyperlipoproteinemia. It can be used together with lifestyle changes such as diet, weight-loss, and exercise.
Uses and Dosage
Fenofibrate Micronized is typically taken once daily in the form of Tablets taken orally as directed by your doctor. Take fenofibrate one time each day as prescribed by your healthcare provider. Take fenofibrate with or without food. Swallow fenofibrate tablets whole. Do not break, crush, dissolve, or chew fenofibrate tablet before swallowing. If you cannot swallow the tablet whole, tell your healthcare provider, you may need a different medicine.
To ensure the greatest benefit, take this medication regularly at the same time each day, based on your medical condition and response to treatment. Do not increase your dose or use it more often or for longer than prescribed, as this will not reduce cholesterol/triglyceride levels more quickly and may increase the risk of side effects. If you are taking other cholesterol-lowering drugs, take fenofibrate at least 1 hour before or at least 4 to 6 hours after these medications to prevent them from binding to fenofibrate and interfering with absorption.
Side Effects
Common Side Effects of Lofibra (Fenofibrate Micronized):
- Headache
- Heartburn (indigestion)
- Increases in muscle or liver enzymes that are measured by blood tests
- Muscle aches
- Nausea
Serious Side Effects of Lofibra (Fenofibrate Micronized):
- Burning eyes
- Chest pain
- Confusion
- Cramps, or weakness
- Dark-colored (brown or red color) urine
- Difficulty breathing
- Fever
- Hives
- Leg muscles that are tender to the touch
- Muscle pain
- Nausea
- Peeling or blistering skin
- Rash
- Sore throat
- Stomach pain
- Swelling of the face, lips, or tongue, closing of the throat
- Swelling of your stomach
- Swelling or warmth in your legs
- Tired
- Vomiting
- Yellowing of your skin or the whites of your eyes
Form and Strength
Lofibra (Fenofibrate Micronized) is available in the following forms and strengths:
Fenofibrate Micronized: Tablet
- 160 mg
Caution
- Lofibra can cause kidney problems, so it should be used with caution in patients who have kidney disease or a history of kidney problems.
- Lofibra can cause liver problems, so it should be used with caution in patients who have liver disease or a history of liver problems.
- Lofibra can cause muscle problems, including muscle pain and weakness. Patients who experience unexplained muscle pain, tenderness or weakness while taking Lofibra should seek medical attention immediately.
- Lofibra can increase the risk of bleeding or blood clotting problems, so it should be used with caution in patients who have a bleeding disorder or are taking blood-thinning medications.
- Lofibra can increase the risk of gallbladder disease, so it should be used with caution in patients who have gallbladder problems.
- Lofibra can increase the risk of liver problems, and alcohol use can also increase this risk. Patients should limit their alcohol consumption while taking this medication.
- Lofibra can increase the risk of pancreatitis (inflammation of the pancreas), so it should be used with caution in patients who have a history of pancreatitis.
- Lofibra can interact with other medications, including blood thinners and cholesterol-lowering drugs, check with your doctor before starting or stopping any medications while taking Lofibra.
- Lofibra can worsen hypothyroidism (underactive thyroid), so it should be used with caution in patients who have this condition.
- Lofibra should not be taken during pregnancy, as it may harm the developing baby. It should only be used in pregnant women if the benefits outweigh the risks.
- Some patients may experience an allergic reaction to Lofibra, which can cause symptoms such as hives, difficulty breathing, and swelling of the face, lips, tongue, or throat. Seek medical attention immediately if you experience any of these symptoms.
Frequently Asked Questions (FAQ)
How long does it take for Lofibra to work?
Lofibra may take several weeks to show its full effect on cholesterol and triglyceride levels. Continue taking the medication as prescribed, even if you feel well.
When can I stop taking fenofibrate?
Liver enzymes need to be periodically monitored and fenofibrate should be discontinued if liver enzymes reach three times the upper limit of normal. In some people, fenofibrate may severely depress HDL cholesterol levels.
Is fenofibrate safe for kidneys?
Fenofibrate is also useful in reducing cardiovascular outcomes and the progression of renal disease among patients with type 2 diabetes not yet requiring dialysis. While the lipid-lowering therapy is effective in patients with the nephrotic syndrome, no long-term outcome studies regarding hard outcomes are available.
How often do I need to check my lipid levels while taking fenofibrate?
Typically, you will need to get lab work done every 4 to 8 weeks to check your cholesterol levels and to see if fenofibrate is working for you.
Resources
It's important to purchase Lofibra from verified Canadian pharmacy.
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