June 15, 2015

Xeljanz vs. Humira

Filed under: Arthritis,joint pain — Tags: , — drwatson @ 9:03 pm

Prescription DrugsHumira and Xelijanz are drugs designed to help treat rheumatoid arthritis. Rheumatoid arthritis is basically a chronic disease that falls under the category of autoimmune disorders. The disease causes the body’s immune system to attack its own, healthy tissue, resulting in swelling, stiffness, and pain in the joints. Both of these drugs can help reduce the significance of these symptoms, and are most beneficial to patients with moderate to severe forms of the disease.

How Do They Work?

Xelijanz is considered a JAK, or “Janus Kinase”, inhibitor. Janus kinases are chemicals within the body that are responsible for triggering inflammation. Inflammation can come in the form of pain, redness, swelling, or a combination of all three. Remember that inflammation is the body attempting to repair itself. Since rheumatoid arthritis is caused by inflammation from the immune response, Xelijanz helps decrease inflammation by lowering immune response.

Humira helps accomplish the same end result, but by an entirely different process. It works on TNF, or “Tumor Necrosis Factor”. TNF is a chemical that occurs naturally in the body, and that is also involved in the immune and inflammatory response. By blocking the actions of TNF in the body, patients are able to experience less pain, swelling, and discomfort caused from rheumatoid arthritis.


Despite their ability to both help treat rheumatoid arthritis, both drugs follow a very different route of administration. Xelijanz should be taken in tablet form. Administration involves 5mg tablets taken twice per day orally. Humira should be taken via injection. Patients should administer a 40mg injection underneath their skin every two weeks.

Side Effects

Like almost all pharmaceutical drugs, both Xelijanz and Humira have side effects that should be noted. Some of the more common side effects associated with Humira include headaches, rashes, and infections. Since the drug ultimately dials down on immune response, patients won’t be able to react as effectively to foreign invaders, resulting in sickness more often than average.

In more serious cases, patients may experience heart failure, leukopenia, hepatic failure, and even cancer. Due to the similarity of both drugs, Xelijanz results in many similar side effects, most of which revolve around soured immune response. Some of these include upper respiratory tract infections, sore throat, diarrhea, headaches, and urinary tract infections.

Which is More Effective?

Both drugs appear to be equally effective, so patients must ultimately decide how they would like to take the medication. A prime advantage Humira is that it only needs to be taken (via injection) once every two weeks, while Xelijanz needs to be taken twice per day, which can be difficult to keep up with.



April 13, 2010

Does Arthritis Ever Go Away?

Arthritis is a chronic illness in which inflammation of a joint occurs. As a result of this disease, those suffering from it feel a lot of pain. Most people start to believe that they will not be able to do the things that they once did. Although there is no cure for Arthritis, there are numerous ways in which people suffering from it can reduce their pain and get back to a normal lifestyle.

Take Medication
A great product to take in order to reduce the effects of Arthritis is Tylenol Arthritis Pain. Tylenol Arthritis Pain acts quickly and works to get rid of the pain as soon as possible. It is an over the counter drug thus easily accessible.

Use Ointments
Applying ointment to the affected area is another great way to quickly get rid of pain. A great product is the A535 Arthritis Rub which is not only cost effective, but also starts relieving pain right from contact.

Apart from medication you can ingest or apply externally, exercise is vital to maintaining a healthy body. For people suffering from Arthritis, exercise will aid in reducing pain and allowing the body to function properly. Although it’s important to consult with your doctor and find out which exercises are safe for you to perform.

Take Rest
Rest and exercise go hand in hand. A balance between the two is an ideal position for Arthritis patients. Resting can reduce inflammation of the joints. However, too much rest can also have a negative impact in that it can result in muscle weakness.

December 21, 2009

4 Ways to Help Prevent Arthritis

Many of us view arthritis as something you only get when you’re old, which is why many people are surprised to learn that they have arthritis at a much younger age. However, the good news is that there are ways to help lower your chances of staying arthritis free for more years to come.

1. Maintain a Healthy Weight – By maintaining a healthy weight, you can help prevent yourself from developing arthritis in your knees, hips, and feet. Being overweight can create a significant amount of strain on your joints and result in permanent damage.

2. Eat Healthy – By eating a healthy, balanced diet you not only maintain a healthy weight, but you give your body the needed nutrients to stay healthy. Vitamins and minerals are important for preventing arthritis.

3. Exercise Often – You need to participate in regular physical activity to stay healthy. By exercising you will help keep healthy muscles and gain many other benefits. However, try to stay away from high impact activities, such as football, basketball, and martial arts. Walking and swimming will be better forms of exercise for those worried about arthritis.

4. Prevent Injuries – Injury prevention is very important to prevent arthritis. Spend extra time making sure you are doing something properly, instead of getting it wrong and hurting yourself. Also, if you do suffer an injury, take time to let it heal fully.

5. Things to Remember – Always, always warm up before exercising. If you go to play a sport, do a quick jog and stretch to warm your muscles up. Wear safety gear, such as a brace or splint on a body part that has recently been injured or may be prone to injury. Make sure you get some rest after strenuous activity. Recovery days are as important as exercising regularly.

December 8, 2008

Can Arava Treat My Rheumatid Arthritis?

Arava is a pyrimidine synthesis inhibitor that is used in the treatment of rheumatoid arthritis. It reduces the pain, stiffness, inflammation, and swelling associated with this disease, improves physical function, and staves off the joint damage that ultimately results

While Arava helps improve symptoms of rheumatoid arthritis such as tenderness and joint swelling, unlike other symptom relievers that focus only on pain relief, Arava slows the advancement of joint damage caused by rheumatoid arthritis

Arava works by reversibly inhibiting the enzyme DHODH that is part of the autoimmune process contributing to the disease. Additionally, Arava is the only oral DMARD indicated to improve physical function.

Before using this medicine, tell your health care provider about any of the following: if you are pregnant, planning to become pregnant, or breastfeeding if you are taking any prescription or nonprescription medicine, if you are allergic to any component present in this medicine.

What Should I Know Before Taking Arava?

  • Arava may interfere with your body’s ability to fight off infection.
  • It can damage your liver or cause blood problems
  • It has been known to cause rare but serious skin reactions
  • It can also reduce your blood cell count.
  • Arava is not recommended for children less than 18 years old.
  • It may take 4 weeks or more to notice any improvement while taking Arava.

What Should I Tell My Doctor Before Using Arava?

  • It is important to tell your doctor if you:
  • Are taking blood thinners
  • Have stomach problems
  • Have peptic ulcers
  • Have liver or kidney function impairment
  • Have a heart problem

What Are the Side Effects?

Most severe: Allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives), heartburn, diarrhea, constipation, nausea, flatulence, headache, weakness, fluid retention, flu-like symptoms

Most common: Anorexia, diarrhea, dyspepsia, gastroenteritis, abnormal liver enzymes, nausea, GI/abdominal pain, mouth ulcer, vomiting

Other: Bronchitis, increased cough, respiratory infection, pharyngitis, pneumonia, rhinitis, sinusitis, alopecia, eczema, pruritus, rash, dry skin

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